Evolution und Infektionsbiologie neuer Influenza-A-Viren mit pandemischem Potenzial
Identifieur interne : 000B44 ( Main/Exploration ); précédent : 000B43; suivant : 000B45Evolution und Infektionsbiologie neuer Influenza-A-Viren mit pandemischem Potenzial
Auteurs : H. D. Klenk [Allemagne]Source :
- Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz [ 1436-9990 ] ; 2013-01-01.
Descripteurs français
- KwdFr :
- Facteurs de risque, Facteurs de virulence (génétique), Grippe humaine (génétique), Grippe humaine (microbiologie), Grippe humaine (épidémiologie), Humains, Modèles génétiques, Pandémies (), Protéines virales (génétique), Prédisposition génétique à une maladie (génétique), Prédisposition génétique à une maladie (épidémiologie), Prévalence, Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité), Évolution moléculaire.
- MESH :
- génétique : Facteurs de virulence, Grippe humaine, Protéines virales, Prédisposition génétique à une maladie, Virus de la grippe A.
- microbiologie : Grippe humaine.
- pathogénicité : Virus de la grippe A.
- épidémiologie : Grippe humaine, Prédisposition génétique à une maladie.
- Facteurs de risque, Humains, Modèles génétiques, Pandémies, Prévalence, Évolution moléculaire.
English descriptors
- KwdEn :
- Evolution, Molecular, Genetic Predisposition to Disease (epidemiology), Genetic Predisposition to Disease (genetics), Host specificity, Humans, Influenza A virus (genetics), Influenza A virus (pathogenicity), Influenza viruses, Influenza, Human (epidemiology), Influenza, Human (genetics), Influenza, Human (microbiology), Models, Genetic, Pandemics, Pandemics (prevention & control), Pandemics (statistics & numerical data), Pathogenicity, Prevalence, Risk Factors, Transmissibility, Viral Proteins (genetics), Virulence Factors (genetics).
- MESH :
- chemical , genetics : Viral Proteins, Virulence Factors.
- epidemiology : Genetic Predisposition to Disease, Influenza, Human.
- genetics : Genetic Predisposition to Disease, Influenza A virus, Influenza, Human.
- microbiology : Influenza, Human.
- pathogenicity : Influenza A virus.
- prevention & control : Pandemics.
- statistics & numerical data : Pandemics.
- Evolution, Molecular, Humans, Models, Genetic, Prevalence, Risk Factors.
Abstract
Zusammenfassung: Influenza-A-Viren kommen natürlicherweise in großer Vielfalt bei Wasservögeln vor. Aufgrund einer hohen genetischen Flexibilität können sie sich bei der Übertragung auf eine andere Spezies (Huhn, Schwein, Mensch) an den neuen Wirt anpassen und dann zum Ausbruch von Tierseuchen und Influenzapandemien führen. Wegen nachgewiesener Humanpathogenität und fehlenden Immunschutzes der Bevölkerung gelten H5N1-, H7N7-, H9N2- und H2N2-Viren als Erreger mit hohem pandemischem Potenzial. Der unerwartete Ausbruch einer H1N1-Pandemie im Jahr 2009 zeigt jedoch, dass die Zuverlässigkeit solcher Vorhersagen begrenzt ist. Wirtsspezifität, Pathogenität und Übertragbarkeit der Viren beruhen auf dem komplexen Wechselspiel der viralen Proteine mit zellulären Faktoren. Zentrale Rollen spielen dabei Rezeptorspezifität und Fusionsaktivität des Hämagglutinins, Kerntransport der Polymerase und Interferonantagonismus des NS1-Proteins.
Abstract: Wild aquatic birds are natural hosts for a large variety of influenza A viruses. Occasionally, viruses are transmitted from this reservoir to other species, such as chickens, pigs, and man, and may then cause devastating outbreaks in domestic poultry or give rise to human influenza pandemics. The H5N1-, H7N7-, H9N2-, and H2N2-viruses are considered to have high pandemic potential, because of their pathogenicity in humans and because of the lack of immune protection in the human population. However, the unexpected outbreak of the H1N1 pandemic in 2009 demonstrates that the reliability of such predictions is limited. Host specificity, pathogenicity, and transmissibility are polygenic traits that depend on the interactions of viral proteins with host factors, among which receptor specificity and fusion activity of the hemagglutinin, nuclear transport of the polymerase, and interferon antagonism of the NS1 protein are of particular importance.
Url:
DOI: 10.1007/s00103-012-1584-2
Affiliations:
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Le document en format XML
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Aufgrund einer hohen genetischen Flexibilität können sie sich bei der Übertragung auf eine andere Spezies (Huhn, Schwein, Mensch) an den neuen Wirt anpassen und dann zum Ausbruch von Tierseuchen und Influenzapandemien führen. Wegen nachgewiesener Humanpathogenität und fehlenden Immunschutzes der Bevölkerung gelten H5N1-, H7N7-, H9N2- und H2N2-Viren als Erreger mit hohem pandemischem Potenzial. Der unerwartete Ausbruch einer H1N1-Pandemie im Jahr 2009 zeigt jedoch, dass die Zuverlässigkeit solcher Vorhersagen begrenzt ist. Wirtsspezifität, Pathogenität und Übertragbarkeit der Viren beruhen auf dem komplexen Wechselspiel der viralen Proteine mit zellulären Faktoren. Zentrale Rollen spielen dabei Rezeptorspezifität und Fusionsaktivität des Hämagglutinins, Kerntransport der Polymerase und Interferonantagonismus des NS1-Proteins.</div><div type="abstract" xml:lang="en">Abstract: Wild aquatic birds are natural hosts for a large variety of influenza A viruses. Occasionally, viruses are transmitted from this reservoir to other species, such as chickens, pigs, and man, and may then cause devastating outbreaks in domestic poultry or give rise to human influenza pandemics. The H5N1-, H7N7-, H9N2-, and H2N2-viruses are considered to have high pandemic potential, because of their pathogenicity in humans and because of the lack of immune protection in the human population. However, the unexpected outbreak of the H1N1 pandemic in 2009 demonstrates that the reliability of such predictions is limited. Host specificity, pathogenicity, and transmissibility are polygenic traits that depend on the interactions of viral proteins with host factors, among which receptor specificity and fusion activity of the hemagglutinin, nuclear transport of the polymerase, and interferon antagonism of the NS1 protein are of particular importance.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Giessen</li><li>Hesse (Land)</li></region><settlement><li>Marbourg</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Klenk, H D" sort="Klenk, H D" uniqKey="Klenk H" first="H. D." last="Klenk">H. D. Klenk</name></region><name sortKey="Klenk, H D" sort="Klenk, H D" uniqKey="Klenk H" first="H. D." last="Klenk">H. D. Klenk</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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